Chromosomal rearrangements have been found to be existing in many forms of cancers such as leukemias and lymphomas. It is believed that chromosomal instability is a great cause for the onset of a certain type of cancer. Chromosomal rearrangements are believed to have an effect on the protooncogenes. Translocation and inversion of a chromosome, in particular, have a significant effect on the protooncogenes. Translocation is particularly important when studying the chromosomal rearrangements leading to cancer. Translocations have .two ways through which they can activate the protooncogenes one in which the overexpression of protooncogenes takes place which happens after the removal of these genes from the elements which hold them. Secondly, these translocations in many tumors form hybrid genes by combining two sets of different genres together.
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by | Mar 12, 2022 | Uncategorized
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